SHORT COMMUNICATION Alternative splicing of p53 and p73: the novel p53 splice variant p53d is an independent prognostic marker in ovarian cancer
نویسندگان
چکیده
Department of Gynecology and Obstetrics, Innsbruck Medical University, Innsbruck, Austria; Laboratory of Molecular Oncology, Department of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia; Department of Obstetrics and Gynecology, Molecular Oncology Group, Medical University of Vienna, Vienna, Austria; Department of Obstetrics and Gynecology, Staedtische Kliniken, Frankfurt, Germany and Ludwig Boltzmann Gesellschaft, Cluster Translational Oncology, Vienna, Austria
منابع مشابه
Ratio disruption of the ∆133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma.
All p53 family members are expressed in several isoforms through alternative promoters and alternative splicing. However, the significance of these isoforms is not yet well understood in cholangiocarcinoma (CCA). In this study, we investigated the expression of p53, p63, p73 and their isoforms at the mRNA and protein levels in CCA. The overexpression of ∆133p53 was observed in the CCA cell line...
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p73 has been recently identified as a new structural and functional homologue of the transcription factor p53. It is expressed in either a full-length form, a , or a shorter b mRNA variant, with exon 13 spliced out. Here we report the identification and functional characterization of two new p73 splicing variants, g (splicing out exon 11) and d (splicing out exons 11, 12, and 13). Both g and d ...
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Background: Prostate cancer is one of the most commonly diagnosed cancers in males. Tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. Objective: To investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. Methods: In this study expression of p53 was examined in p...
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p53 is an important tumor suppressor gene, which is stimulated by cellular stress like ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to cell-cycle arrest and promotes DNA repair or induces apoptosis via several pathways. p63 and p73 are structural homologs of p53 that can act similarly to the protein and also hold functions distinct from p53. Today m...
متن کاملTwo New p73 Splice Variants, γ and δ, with Different Transcriptional Activity
p73 has been recently identified as a new structural and functional homologue of the transcription factor p53. It is expressed in either a full-length form, alpha, or a shorter beta mRNA variant, with exon 13 spliced out. Here we report the identification and functional characterization of two new p73 splicing variants, gamma (splicing out exon 11) and delta (splicing out exons 11, 12, and 13)....
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